Lab focus
The goal of our group is to study how deficits in brain development affect cognitive function. We start from the identification of genes which cause neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, or brain malformations, and then use animal models (mouse and zebrafish) to recapitulate the human disease, understand pathogenesis and study the molecular mechanisms of development. We are particularly interested in intracellular signaling and glycosylation deficits that could be targeted for the development of novel therapies.
Contact
M. Chiara Manzini PhD
Child Health Institute of New Jersey
Rutgers-Robert Wood Johnson Medical School
Dept. of Neuroscience and Cell Biology
89 French Street rm 3274
New Brunswick, NJ 08901
Child Health Institute of New Jersey
Rutgers-Robert Wood Johnson Medical School
Dept. of Neuroscience and Cell Biology
89 French Street rm 3274
New Brunswick, NJ 08901
Latest lab news
2/1/24 - Sylvia's thesis work in collaboration with Kyle defining the genetic causes of severe congenital muscular dystrophy with brain malformations in Egypt is out in neurogenetics. Open Access at Springer.
1/25/24 - One more paper out this week. Brittany Karas and Kristin Terez' major opus on the zebrafish pomt1 mutant model of congenital muscle disease showing that "Moms matter". Available online at OUP.
1/18/24 - See new guidelines for drug screening in zebrafish muscle disease models we contributed to in collaboration with multiple investigator led by Matt Alexander at UAB. Published in Disease Models & Mechanisms today.
12/15/23 - We have a new position open for a research assistant working with Kyle and Shorbon on zebrafish models of muscle disease. Click here to apply
12/15/23 - We have a new position open for a research assistant working with Aniket on iPSC models of intellectual disability and autism with particular focus on sex differences. Click here to apply.
11/27/23 - Sylvia Safwat MD defended her PhD at Alexandria University including data she collected in our lab during her visit. She's now Dr Dr Sylvia!!
11/15/23 - Brittany Karas is leaving the lab to take a position as Toxicologist at Johnson & Johnson!
10/26/23 - As part of an ongoing collaboration with Daniel Burbano at the Rutgers School of Engineering we just participated in a cool study on zebrafish emotional contagion. Out today in Behavioural Processes.
2/1/24 - Sylvia's thesis work in collaboration with Kyle defining the genetic causes of severe congenital muscular dystrophy with brain malformations in Egypt is out in neurogenetics. Open Access at Springer.
1/25/24 - One more paper out this week. Brittany Karas and Kristin Terez' major opus on the zebrafish pomt1 mutant model of congenital muscle disease showing that "Moms matter". Available online at OUP.
1/18/24 - See new guidelines for drug screening in zebrafish muscle disease models we contributed to in collaboration with multiple investigator led by Matt Alexander at UAB. Published in Disease Models & Mechanisms today.
12/15/23 - We have a new position open for a research assistant working with Kyle and Shorbon on zebrafish models of muscle disease. Click here to apply
12/15/23 - We have a new position open for a research assistant working with Aniket on iPSC models of intellectual disability and autism with particular focus on sex differences. Click here to apply.
11/27/23 - Sylvia Safwat MD defended her PhD at Alexandria University including data she collected in our lab during her visit. She's now Dr Dr Sylvia!!
11/15/23 - Brittany Karas is leaving the lab to take a position as Toxicologist at Johnson & Johnson!
10/26/23 - As part of an ongoing collaboration with Daniel Burbano at the Rutgers School of Engineering we just participated in a cool study on zebrafish emotional contagion. Out today in Behavioural Processes.